Signal intensity in the dentate nucleus after cumulative dose of Gd-EOB-DTPA: First results of a prospective longitudinal study.

Katharina Michalik, Lukas Beyer, Florian Zeman, Christina Wendl, Janine Rennert, Claudia Fellner, Christian Stroszczynski, Philipp Wiggermann

Clinical hemorheology and microcirculation 2020

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Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific, linear ionic contrast agent for MRI. In comparison to other linear contrast agents Gd-EOB-DTPA is excreted equally through liver and kidneys. This prospective longitudinal study investigates the signal intensity (SI) in the dentate nucleus (DN) on unenhanced T1-weighted images after repetitive application of Gd-EOB-DTPA. 46 patients were included into the study and 107 MRI examinations were performed. Statistical analysis of 25 patients showed no significant correlation between cumulative dose of Gd-EOB-DTPA and SI change and between the DN/Pons ratiolast and the mean DN/Pons ratiofirst. Subgroup analysis however revealed a significant correlation for one out of two readers. Gd-EOB-DTPA deposition could not be proven in the framework of this study.

Citation

Katharina Michalik, Lukas Beyer, Florian Zeman, Christina Wendl, Janine Rennert, Claudia Fellner, Christian Stroszczynski, Philipp Wiggermann. Signal intensity in the dentate nucleus after cumulative dose of Gd-EOB-DTPA: First results of a prospective longitudinal study. Clinical hemorheology and microcirculation. 2020;76(2):233-240