The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF-kappaB pathway.

Pegah Dejban, Nasrin Nikravangolsefid, Mohsen Chamanara, Ahmadreza Dehpour, Amir Rashidian

Phytotherapy research : PTR 2021 Feb

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Inflammatory bowel disease (IBD) is a lifelong and recurrent disease of the gastrointestinal tract that afflicts many people in the world. Growing evidence has currently indicated that dysfunction of immune system, particularly toll-like receptors 4 (TLR4) signaling pathway dysfunction plays a pivotal part in the pathogenesis of IBD. TLR4 signaling is involved both in the pathogenesis and in the efficacy of treatment of IBD. There are some medicinal products and herbal medicines, which their role in the treatment of IBD through modulation of TLR4 signaling has been implicated. The purpose of this review article is to summarize those medicinal products and herbal medicines. © 2020 John Wiley & Sons Ltd.

Citation

Pegah Dejban, Nasrin Nikravangolsefid, Mohsen Chamanara, Ahmadreza Dehpour, Amir Rashidian. The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF-kappaB pathway. Phytotherapy research : PTR. 2021 Feb;35(2):835-845