Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain.

Lucas Schirmer, Chloé Hoornaert, Debbie Le Blon, Dimitri Eigel, Catia Neto, Mark Gumbleton, Petra B Welzel, Anne E Rosser, Carsten Werner, Peter Ponsaerts, Ben Newland

Biomaterials science 2020 Sep 15

filter terms:

Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.

Citation

Lucas Schirmer, Chloé Hoornaert, Debbie Le Blon, Dimitri Eigel, Catia Neto, Mark Gumbleton, Petra B Welzel, Anne E Rosser, Carsten Werner, Peter Ponsaerts, Ben Newland. Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain. Biomaterials science. 2020 Sep 15;8(18):4997-5004