Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population.

Chronic obstructive pulmonary disease (COPD) is the result of interaction between genetic and environmental factors. In this study, we aimed to explore whether MIR2113 and MIR129-LEP polymorphisms confer susceptibility to COPD. We selected five polymorphisms of two genes (MIR2113: rs2505059 and rs9320913; MIR129-LEP: rs7778167, rs791595 and rs4731420) based on previous studies and genotyped 629 samples, which included 315 COPD patients and 314 controls with Agena MassARRAY platform. The association of MIR2113 and MIR129-LEP polymorphisms with COPD risk was conducted with logistic regression by calculating odd ratios (OR) and 95% confidence intervals (CI). MIR2113 rs2505059 was remarkably linked with a decreased susceptibility of COPD in five genetic models, whereas MIR2113 rs9320913, MIR129-LEP rs791595 and MIR129-LEP rs4731420 could enhance the susceptibility of COPD in the Chinese Han population (P < 0.05). Stratified analysis revealed that the influences of genetic variants on COPD risk were dependent on age, sex, Body mass index or smoking status (P < 0.05). Haplotype analysis showed that Ars791595Crs4731420 haplotype significant increased the susceptibility of COPD. It suggested that polymorphisms of MIR2113 and MIR129-LEP might be linked with the susceptibility of COPD among the Chinese Han population. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Jing Jing, Dan Xu, Zheng Li, Min Jiang, Jing Wang, Jian Zhang. Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population. Pulmonary pharmacology & therapeutics. 2020 Oct;64:101945

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PMID: 32931917

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