Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Cathepsins have emerged as important targets in various tissues degenerative disorders due to their involvement in degradation of extracellular matrices and endogenous protein turnover. Elevated cathepsins levels vis-à-vis decreased concentration of endogenous inhibitors has been reported at different diseased sites. The design and synthesis of specific potential anti-cathepsin agents is therefore of great significance. Most of potential anti-cathepsin agents developed have peptide based structures with an active warhead. Due to oral instability and immunogenic problems related to peptidyl inhibitors drift the synthesis and evaluation of non-peptide cathepsin inhibitors in last two decades. The present work provides a detailed structure activity relationship for developing potential non-peptide anticathepsin agents based on in-vitro inhibition studies of a library of synthesized thiocarbamoyl- non-peptide inhibitors. Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Ravinder Kaur, Neera Raghav. Some thiocarbamoyl based novel anticathepsin agents. Bioorganic chemistry. 2020 Nov;104:104174

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 32932119

View Full Text