Specialized regulatory T cells control venous blood clot resolution through SPARC.

Fatemeh Shahneh, Alexandra Grill, Matthias Klein, Felix Frauhammer, Tobias Bopp, Katrin Schäfer, Verena K Raker, Christian Becker

Blood 2021 Mar 18

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The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg population that forms the matricellular acid- and cysteine-rich protein SPARC (secreted protein acidic and rich in cysteine) and show that SPARC enhances monocyte MMP activity and that SPARC+ Tregs are crucial for blood clot resorption. By comparing different treatment times, we define a therapeutic window of Treg expansion that accelerates clot resorption. © 2021 by The American Society of Hematology.

Citation

Fatemeh Shahneh, Alexandra Grill, Matthias Klein, Felix Frauhammer, Tobias Bopp, Katrin Schäfer, Verena K Raker, Christian Becker. Specialized regulatory T cells control venous blood clot resolution through SPARC. Blood. 2021 Mar 18;137(11):1517-1526