A New Method for the Synthesis of 3-Thiocyanatopyrazolo[1,5-a]pyrimidines.

Vladimir A Kokorekin, Sergey V Neverov, Vera N Kuzina, Vladimir A Petrosyan

Molecules (Basel, Switzerland) 2020 Sep 11

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In this article, we demonstrate how an original effective "metal-free" and "chromatography-free" route for the synthesis of 3-thiocyanatopyrazolo[1,5-a]pyrimidines has been developed. It is based on electrooxidative (anodic) C-H thiocyanation of 5-aminopyrazoles by thiocyanate ion leading to 4-thiocyanato-5-aminopyrazoles (stage 1, yields up to 87%) following by their chemical condensation with 1,3-dicarbonyl compounds or their derivatives (stage 2, yields up to 96%). This method is equally effective for the synthesis of 3-thiocyanatopyrazolo[1,5-a]pyrimidines, both without substituents and with various donor (acceptor) substituents in the pyrimidine ring.

Citation

Vladimir A Kokorekin, Sergey V Neverov, Vera N Kuzina, Vladimir A Petrosyan. A New Method for the Synthesis of 3-Thiocyanatopyrazolo[1,5-a]pyrimidines. Molecules (Basel, Switzerland). 2020 Sep 11;25(18)