Development of differentiation modulators and targeted agents for treating neuroblastoma.

Zegao Jin, Yang Lu, Yizhe Wu, Jinxin Che, Xiaowu Dong

European journal of medicinal chemistry 2020 Dec 01

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Neuroblastoma (NB) is one of the most common pediatric malignancies. Easy metastasis, poor prognosis, and a high degree of heterogeneity of NB hinder its successful treatment. Several different therapeutic strategies have been developed to overcome these problems, including differentiation and targeted therapy. In this review, we summarize the recent development of differentiation modulators and targeted agents for treating NB. Several promising targets of NB were also discussed. Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Citation

Zegao Jin, Yang Lu, Yizhe Wu, Jinxin Che, Xiaowu Dong. Development of differentiation modulators and targeted agents for treating neuroblastoma. European journal of medicinal chemistry. 2020 Dec 01;207:112818