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In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.


Jhansi L Leslie, Erin Weddle, Lauren K Yum, Ye Lin, Matthew L Jenior, Benjamin Lee, Jennie Z Ma, Beth D Kirkpatrick, Uma Nayak, James A Platts-Mills, Herve F Agaisse, Rashidul Haque, William A Petri. Lewis Blood Group Antigens are Associated with Altered Susceptibility to Shigellosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 Sep 17

PMID: 32940644

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