Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress.

We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells. In addition to increased methylation of chromatin proteins that favors senescence-associated secretory phenotype (SASP) activation, our study unraveled global hypo-methylation of RNA-binding proteins, which - we speculate - may promote their phase separation and stress granules formation. © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

Citation

Roberto Giambruno, Tiziana Bonaldi. Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress. Molecular & cellular oncology. 2020;7(4):1743808

PMID: 32944613

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