Correlation Engine 2.0
Clear Search sequence regions

  • brain (2)
  • female (1)
  • humans (1)
  • infant (1)
  • patients (3)
  • spasms (6)
  • vigabatrin (8)
  • Sizes of these terms reflect their relevance to your search.

    Vigabatrin (VGB), adrenocorticotropic hormone (ACTH), and prednisone are first-line treatments for infantile spasms (IS). A recent study reported benefits from the use of combination VGB and hormonal therapy over hormonal treatment alone in IS. We describe three patients with IS who developed acute encephalopathy with extrapyramidal symptoms, vigabatrin-associated brain abnormalities on magnetic resonance imaging (VABAM), and death in one patient shortly after initiation of therapy with VGB and ACTH. A literature review supports increased risk of fulminant, symptomatic VABAM in patients receiving VGB in association with hormonal therapy, raising concerns regarding its safety in IS. © 2020 International League Against Epilepsy.


    Sonam Bhalla, Karen Skjei. Fulminant vigabatrin toxicity during combination therapy with adrenocorticotropic hormone for infantile spasms: Three cases and review of the literature. Epilepsia. 2020 Oct;61(10):e159-e164

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32944947

    View Full Text