White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells.

Cheng-Chih Hsiao, Nina L Fransen, Aletta M R van den Bosch, Kim I M Brandwijk, Inge Huitinga, Jörg Hamann, Joost Smolders

European journal of immunology 2021 Feb

filter terms:

Brain CD8+ CD69+ tissue-resident memory T (TRM ) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS. © 2020 Wiley-VCH GmbH.

Citation

Cheng-Chih Hsiao, Nina L Fransen, Aletta M R van den Bosch, Kim I M Brandwijk, Inge Huitinga, Jörg Hamann, Joost Smolders. White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells. European journal of immunology. 2021 Feb;51(2):483-486