The Class A Carbapenemases BKC-1 and GPC-1 Both Originate from the Bacterial Genus Shinella.

Nicolas Kieffer, Stefan Ebmeyer, D G Joakim Larsson

Antimicrobial agents and chemotherapy 2020 Nov 17

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Comparative genomics identified the environmental bacterial genus Shinella as the most likely origin of the class A carbapenemases BKC-1 and GPC-1. Available sequences and PCR analyses of additional Shinella species revealed homologous β-lactamases showing up to 85.4% and 93.3% amino acid identity to both enzymes, respectively. The genes conferred resistance to β-lactams once expressed in Escherichia coli bla BKC-1 likely evolved from a putative ancestral Shinella gene with higher homology through duplication of a gene fragment. Copyright © 2020 Kieffer et al.

Citation

Nicolas Kieffer, Stefan Ebmeyer, D G Joakim Larsson. The Class A Carbapenemases BKC-1 and GPC-1 Both Originate from the Bacterial Genus Shinella. Antimicrobial agents and chemotherapy. 2020 Nov 17;64(12)