Impact of the beta-lacta test on the management of urinary tract infections at the emergency department.

Assaf Mizrahi, Diane Naouri, Claire Hobson, Jonas Amzalag, Benoît Pilmis, Carine Couzigou, Olivier Ganansia, Alban Le Monnier

Infectious diseases (London, England) 2021 Jan

filter terms:

Rapid detection of extended-spectrum β-lactamases is essential. In this study, we evaluated the potential impact of β-lacta test on both the times to appropriate antibiotic therapy and to the implementation of patient isolation measures. We included prospectively all the patients admitted to the emergency department for clinical suspicion of urinary tract infection. Compared with physician's decision, we analysed the potential impact of β-lacta test on the initial antibiotic therapy and on the implementation of hygiene measures. This study has been registered under number NCT02897609. We included 203 patients, 43% with acute pyelonephritis and 21% with acute prostatitis. The β-lacta test had a 95.2% sensitivity and a 99.5% specificity to detect extended-spectrum β-lactamases. Taking the β-lacta test results into account would have decreased significantly both the times to appropriate therapy and to isolation measures from 54 to 2.7 h and from 55.2 to 2.6 h, respectively. The β-lacta test could reduce significantly the times to appropriate therapy and implementation of isolations measures.

Citation

Assaf Mizrahi, Diane Naouri, Claire Hobson, Jonas Amzalag, Benoît Pilmis, Carine Couzigou, Olivier Ganansia, Alban Le Monnier. Impact of the beta-lacta test on the management of urinary tract infections at the emergency department. Infectious diseases (London, England). 2021 Jan;53(1):52-60