Diagnostic and Prognostic Roles of Serum Interleukin-6 Levels in Patients with Uveitis.

Arash Maleki, Sebastian Gomez, Soheila Asgari, Zoe Bosenberg, Ambika Manhapra, Marisa Walsh, Angelina Weng, Catherine Tsang, Celestine He, Stephen Damien Anesi, C Stephen Foster

Ocular immunology and inflammation 2022 Feb 17

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To examine the diagnostic and prognostic roles of serum interleukin-6 levels in patients with uveitis. This was a retrospective observational case series. Demographic and clinical characteristics were compared between Group One (sixty patients) with normal serum IL-6 levels and Group Two (twenty patients) with high serum interleukin-6 levels. Mean IL-6 level was 1.77 ± 0.97 pg/ml and 10.2 ± 9.7 pg/ml in Group One and Group Two respectively. Age, presence of systemic disease, and mean number of flare-ups were statistically significant (p = .015, p = .000, p = .03, respectively). Multivariate analysis was performed on variables that were statistically significant in univariate analysis and showed that three variables had significant correlation with IL-6 levels in both groups: systemic disease (OR = 10.83, p < .001), Age (OR = 0.95, p = .03) and number of flare-ups (OR = 2.9, p = .02). Serum IL-6 levels can provide diagnostic and prognostic information in regard to the course of disease and its treatment.

Citation

Arash Maleki, Sebastian Gomez, Soheila Asgari, Zoe Bosenberg, Ambika Manhapra, Marisa Walsh, Angelina Weng, Catherine Tsang, Celestine He, Stephen Damien Anesi, C Stephen Foster. Diagnostic and Prognostic Roles of Serum Interleukin-6 Levels in Patients with Uveitis. Ocular immunology and inflammation. 2022 Feb 17;30(2):457-462