Adalimumab-associated Acquired Hemophilia in a Patient with Scleritis.

Paulina Liberman, Bryn M Burkholder

Ocular immunology and inflammation 2022 Feb 17

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Acquired hemophilia A (AHA) is a rare condition that may be drug-induced. In this case report, we describe a patient who presented with extensive subcutaneous bleeding three years after beginning treatment with adalimumab for necrotizing scleritis. His workup was compatible with drug-induced AHA. He was treated with high-dose corticosteroids, cyclophosphamide, and rituximab. Adalimumab was discontinued. We present this case as an example of a rare, but potentially life-threatening, complication of adalimumab.

Citation

Paulina Liberman, Bryn M Burkholder. Adalimumab-associated Acquired Hemophilia in a Patient with Scleritis. Ocular immunology and inflammation. 2022 Feb 17;30(2):294-296