Correlation Engine 2.0
Clear Search sequence regions

  • apoptosis (2)
  • calcium (2)
  • cancer (2)
  • colitis (6)
  • colon cancer (1)
  • crc (8)
  • EMR1 (1)
  • flavonoids (2)
  • G Protein (2)
  • human cells (2)
  • humans (1)
  • Ki67 (1)
  • mice (7)
  • plant extracts (2)
  • polyphenol (4)
  • polyps (1)
  • receptors (2)
  • resin (1)
  • semen (2)
  • sodium (1)
  • spinosin (4)
  • ziziphus (1)
  • Sizes of these terms reflect their relevance to your search.

    Homology of medicine and food-zizyphi spinosi semen (ZSS) exhibits abundant pharmacological activities, such as sedation, hypnosis and anti-depression. In the present study, the water soluble polyphenols extracted from ZSS via the acid digestion method were named ZSSP, and exhibited significant anti-colorectal cancer (CRC) activity, characterized by restraining cell proliferation, promoting cell apoptosis and increasing chemo-sensitivity of CRC cells. The potential of ZSSP in vivo was further evaluated in an AOM/DSS-induced colitis-associated carcinogenesis (CAC) mouse model. Intriguingly, ZSSP diminished the number and volume of CAC polyps in mice in a dose-dependent manner, and effectively limited the damage of mice organs induced by AOM/DSS. The immunohistochemistry result showed that the elevated CRC early markers in CAC mice, such as COX-II, EMR1, and Ki67, were potently prevented by the ZSSP treatment. Further, the component in ZSSP with the anti-CRC activity was identified as spinosin by the macroporous resin of SP207 and RP-HPLC-MS/MS. Interestingly, during the extraction process, sodium ions were introduced forming spinosin·Na+, which had better water solubility and more remarkable anti-CRC activity than the spinosin. This study provides a new pharmacological property of spinosin derived from ZSS, inhibiting the growth of human CRC cells and colitis-associated CRC in mice, which indicates its potential use as a natural agent against CRC.


    Shuhua Shan, Yue Xie, Chengying Zhang, Bin Jia, Hanqing Li, Zhuoyu Li. Identification of polyphenol from Ziziphi spinosae semen against human colon cancer cells and colitis-associated colorectal cancer in mice. Food & function. 2020 Sep 23;11(9):8259-8272

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32966479

    View Full Text