MiR-370-5p inhibits the progression of breast cancer via targeting LUC7L3.

Kai Sang, Tongbo Yi, Xinxin Huang, Chi Pan, Jian Zhou, Lei Yu

Journal of receptor and signal transduction research 2021 Oct

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Breast cancer is one of the most common malignancies and one of the leading causes of cancer-induced mortality among women. Over the past decades, the occurrence of breast cancer has been a significant increase. As documented in numerous researches, microRNAs (miRNAs) play vital roles in a wide range of biological processes associated with the occurrence and development of breast cancer. Nevertheless, the role of miR-370-5p in breast cancer remains obscure, and the possible molecular regulatory mechanism needs to be further explored. In this study, our results delineated that miR-370-5p was downregulated in breast cancer tissues and cell lines. Besides, miR-370-5p overexpression suppressed cell proliferation and invasion in breast cancer. MiR-370-5p downregulation exerted an opposite result. In addition, LUC7L3 was identified as a target gene for miR-370-5p. Similar with the results induced by miR-370-5p overexpression, LUC7L3 knockdown attenuated the proliferation and invasion ability of breast cancer cells. Moreover, the alternation of LUC7L3 expression reversed the regulatory effects of miR-370-5p on cell phenotypes in breast cancer. Overall, miR-370-5p may exert antitumor effect on breast cancer. Hence, miR-370-5p may serve as a novel therapeutic marker for the treatment of patients with breast cancer.

Citation

Kai Sang, Tongbo Yi, Xinxin Huang, Chi Pan, Jian Zhou, Lei Yu. MiR-370-5p inhibits the progression of breast cancer via targeting LUC7L3. Journal of receptor and signal transduction research. 2021 Oct;41(5):442-450