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Osmotic stress signaling in higher plants is crucial to cope with abiotic stress. RAF-like MAPKKKs are activated by hyperosmotic stress and activate downstream ABA-unresponsive and ABA-activated SnRK2s, integrating early osmotic stress and ABA signaling cascades. The connection of B2/B3/B4 RAF-like MAPKKKs with SnRK2s is a new paradigm in signal transduction. Copyright © 2020 Elsevier Ltd. All rights reserved.


Jorge Lozano-Juste, Abdulwahed F Alrefaei, Pedro L Rodriguez. Plant Osmotic Stress Signaling: MAPKKKs Meet SnRK2s. Trends in plant science. 2020 Dec;25(12):1179-1182

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PMID: 32972846

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