Diamine Biosynthesis: Research Progress and Application Prospects.

Li Wang, Guohui Li, Yu Deng

Applied and environmental microbiology 2020 Nov 10

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Diamines are important monomers for polyamide plastics; they include 1,3-diaminopropane, 1,4-diaminobutane, 1,5-diaminopentane, and 1,6-diaminohexane, among others. With increasing attention on environmental problems and green sustainable development, utilizing renewable raw materials for the synthesis of diamines is crucial for the establishment of a sustainable plastics industry. Recently, high-performance microbial factories, such as Escherichia coli and Corynebacterium glutamicum, have been widely used in the production of diamines. In particular, several synthetic pathways of 1,6-diaminohexane have been proposed based on glutamate or adipic acid. Here, we reviewed approaches for the biosynthesis of diamines, including metabolic engineering and biocatalysis, and the application of bio-based diamines in nylon materials. The related challenges and opportunities in the development of renewable bio-based diamines and nylon materials are also discussed. Copyright © 2020 American Society for Microbiology.

Citation

Li Wang, Guohui Li, Yu Deng. Diamine Biosynthesis: Research Progress and Application Prospects. Applied and environmental microbiology. 2020 Nov 10;86(23)