Mechanisms of Transcription Elongation Factor DSIF (Spt4-Spt5).

The transcription elongation factor Spt5 is conserved from bacteria to humans. In eukaryotes, Spt5 forms a complex with Spt4 and regulates processive transcription elongation. Recent studies on transcription elongation suggest different mechanistic roles in yeast versus mammals. Higher eukaryotes utilize Spt4-Spt5 (DSIF) to regulate promoter-proximal pausing, a transcription-regulatory mechanism that connects initiation to productive elongation. DSIF is a versatile transcription factor and has been implicated in both gene-specific regulation and transcription through nucleosomes. Future studies will further elucidate the role of DSIF in transcriptional dynamics and disentangle its inhibitory and enhancing activities in transcription. Copyright © 2020 Elsevier Ltd. All rights reserved.

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Tim-Michael Decker. Mechanisms of Transcription Elongation Factor DSIF (Spt4-Spt5). Journal of molecular biology. 2021 Jul 09;433(14):166657

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PMID: 32987031

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