Lysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B.

Jitender Yadav, Sana Ismaeel, Ayub Qadri

Antimicrobial agents and chemotherapy 2020 Nov 17

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Polymyxin B, used to treat infections caused by antibiotic-resistant Gram-negative bacteria, produces nephrotoxicity at its current dosage. We show that a combination of nonbactericidal concentration of this drug and lysophosphatidylcholine (LPC) potently inhibits growth of Salmonella and at least two other Gram-negative bacteria in vitro This combination makes bacterial membrane porous and causes degradation of DnaK, the regulator of protein folding. Polymyxin B-LPC combination may be an effective and safer regimen against drug-resistant bacteria. Copyright © 2020 American Society for Microbiology.

Citation

Jitender Yadav, Sana Ismaeel, Ayub Qadri. Lysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B. Antimicrobial agents and chemotherapy. 2020 Nov 17;64(12)