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The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain transmission both in peripheral and central nervous system (CNS). Despite evidence of a pro-nociceptive role of BDNF, recent studies have reported contrasting results, including anti-nociceptive and anti-inflammatory activities. Moreover, BDNF polymorphisms can interfere with BDNF role in pain perception. In Val66Met carriers, the Met allele may have a dual role, with anti-nociceptive actions in normal condition and pro-nociceptive effects during chronic pain. In order to elucidate the main effects of BDNF in nociception, we reviewed the main characteristics of this neurotrophin, focusing on its involvement in pain. Copyright © 2020 Elsevier B.V. All rights reserved.


Natalia Cappoli, Elisabetta Tabolacci, Paola Aceto, Cinzia Dello Russo. The emerging role of the BDNF-TrkB signaling pathway in the modulation of pain perception. Journal of neuroimmunology. 2020 Dec 15;349:577406

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PMID: 33002723

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