Correlation Engine 2.0
Clear Search sequence regions


  • 4 and (3)
  • 5 bt (1)
  • acyl (2)
  • Akt (73)
  • alkyl (1)
  • amino acid (1)
  • apoptosis (3)
  • arabidopsis (1)
  • ATP (3)
  • b cell (1)
  • b t cell receptor (1)
  • basic fibroblast growth factor (1)
  • bind proteins (2)
  • breast cancer (2)
  • calcium (1)
  • cancer (25)
  • case (3)
  • cell cycle (1)
  • cell growth (3)
  • cellular (12)
  • cholesterol (1)
  • cisplatin (2)
  • Cnk1 (2)
  • colon carcinoma (1)
  • cycle cell (1)
  • cytoplasm (1)
  • diacylglycerol (1)
  • dimers protein (1)
  • direct (1)
  • embryo (1)
  • ether (3)
  • FGF 2 (3)
  • fibroblasts (1)
  • gene (1)
  • glycogen (1)
  • growth factors (2)
  • growth hormones (1)
  • growth normal (1)
  • h 37 (1)
  • hand weak (1)
  • human (2)
  • human cells (1)
  • hydroxyls (1)
  • inositol (49)
  • ins 1, 3, 4, 5) p 4 (6)
  • insulin (2)
  • insulin receptor (1)
  • IP6K1 (1)
  • isoform (2)
  • Itk (3)
  • ligands (1)
  • lipids (8)
  • lysophospholipid (1)
  • metastasis (1)
  • minor (1)
  • mk 2206 (1)
  • mutagenesis (1)
  • ovarian cancer (1)
  • p110β (1)
  • p110γ (2)
  • p110δ (1)
  • PANC1 (1)
  • parent (2)
  • past (2)
  • PDK1 (15)
  • PH (55)
  • ph domains bind (2)
  • phase (1)
  • phosphatases (1)
  • phosphoinositides (63)
  • PI3K (28)
  • PIK3CA (3)
  • pinocytosis (1)
  • plasma membrane (14)
  • platelet (1)
  • pleckstrin (1)
  • polyphosphates (23)
  • pro drug (1)
  • prostate (1)
  • protein complex (2)
  • protein domains (9)
  • protein membrane (3)
  • proteins Vac1 (1)
  • PTEN (4)
  • rapamycin (2)
  • Ras 1 (1)
  • receptor (3)
  • signals (1)
  • small cell lung carcinoma (4)
  • stem cells (1)
  • subunits (3)
  • suggests (3)
  • tandem repeats (1)
  • target drugs (2)
  • target proteins (2)
  • xenograft (2)
  • zebrafish (1)
  • zinc finger (1)
  • Sizes of these terms reflect their relevance to your search.

    Signaling pathways regulated by the phosphoinositide 3-kinase (PI3K) enzymes have a well-established role in cancer development and progression. Over the past 30 years, the therapeutic potential of targeting this pathway has been well recognized, and this has led to the development of a multitude of drugs, some of which have progressed into clinical trials, with few of them currently approved for use in specific cancer settings. While many inhibitors compete with ATP, hence preventing the catalytic activity of the kinases directly, a deep understanding of the mechanisms of PI3K-dependent activation of its downstream effectors led to the development of additional strategies to prevent the initiation of this signaling pathway. This review summarizes previously published studies that led to the identification of inositol polyphosphates as promising parent molecules to design novel inhibitors of PI3K-dependent signals. We focus our attention on the inhibition of protein-membrane interactions mediated by binding of pleckstrin homology domains and phosphoinositides that we proposed 20 years ago as a novel therapeutic strategy.

    Citation

    Tania Maffucci, Marco Falasca. Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling. International journal of molecular sciences. 2020 Sep 29;21(19)

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33003448

    View Full Text