BaseSpace
Import Your Data
Literature

FAQ

More FAQs

Back to top
Clear Search sequence regions
(e.g. PTEN, calcium channel activity, Diabetes mellitus, Hippocampus, Alcohol, Fenofibrate)
Bookmark Forward

Recombinant subgroup B avian leukosis virus combined with the subgroup J env gene significantly increases its pathogenicity.

Qiuhong Li, Peikun Wang, Min Li, Lulu Lin, Mengya Shi, Haijuan Li, Qiaomu Deng, Huang Teng, Meilan Mo, Tianchao Wei, Ping Wei

Veterinary microbiology 2020 Nov


filter terms:
  • avian leukosis (1)
  • avian leukosis virus (12)
  • birds (3)
  • chickens (2)
  • env gene (3)
  • fibroblasts (1)
  • genes env (1)
  • oil (1)
  • receptors (1)
  • subgroup b (2)
  • tropism (2)
  • vaccines (1)
  • viremia (1)
  • weight gain (1)
    • Sizes of these terms reflect their relevance to your search.

    The differences among different sub-groups of the avian leukosis virus (ALV) genome are mainly concentrated in the env gene, which binds to cell-specific receptors and determines the characteristics of viral tropism and pathogenicity. In this study, two rescued viruses rGX15MM6-2 (ALV of subgroup J, ALV-J) and rGX14FF03 (ALV of subgroup B, ALV-B) and a recombinant virus rALV-B-Jenv (ALV-B's backbone with ALV-J's env) were generated and tested utilizing both in vitro and in vivo experiments. The results showed that the replication ability of the viruses released in DF-1 cell cultures was listed in order as rGX15MM6-2 > rALV-B-Jenv > rGX14FF03. rGX15MM6-2 caused the most serious suppression of body weight gain, exhibited a significant negative effect on the development of immune organs (P < 0.05) and lower antibody responses to vaccinations with the commercial oil-emulsion vaccines (OEVs) (P<0.05) in the challenged chickens. The viral detection showed that the positive rate in blood from the birds infected with rALV-B-Jenv were respectively higher than those from the birds infected with rGX14FF03 (P < 0.05). At 25 wpi, similar tumors were found in the abdominal cavity of the birds in rGX15MM6-2 and rALV-B-Jenv groups. The results demonstrated that the ALV-J env gene significantly increases the pathogenicity of the recombinant ALV-B. With the increasing incidence of co-infections of different subgroups of ALV in the field, the possibility of viral recombination is increasing and demands further study. Copyright © 2020 Elsevier B.V. All rights reserved.

    Citation

    Qiuhong Li, Peikun Wang, Min Li, Lulu Lin, Mengya Shi, Haijuan Li, Qiaomu Deng, Huang Teng, Meilan Mo, Tianchao Wei, Ping Wei. Recombinant subgroup B avian leukosis virus combined with the subgroup J env gene significantly increases its pathogenicity. Veterinary microbiology. 2020 Nov;250:108862

    Expand section icon Mesh Tags


    PMID: 33007608

    View Full Text
    • Copyright © 2025 Illumina Inc. All rights reserved.