Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice.

Carlos M Donado-Pestana, Érika V M Pessoa, Larissa Rodrigues, Rafaela Rossi, Márcio H C Moura, Priscila R Dos Santos-Donado, Érique Castro, William T Festuccia, Maria Inés Genovese

Food chemistry 2021 Mar 15

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Polyphenols from cambuci (CBC) (Campomanesia phaea (O. Berg.)), a Brazilian native fruit, were investigated on therapeutic actions mitigating insulin resistance and hepatic steatosis in high-fat-sucrose diet (HFS) induced obese mice. For this, C57BL/6J mice fed with a obesogenic and diabetogenic HFS diet were administered with either water or two CBC doses (36 or 74 mg gallic acid equivalent (GAE)/kg body weight) by gavage from week 6 to week 14 (end-point) of HFS feeding. CBC reduced body weight gain, inflammation, hepatic steatosis, hyperglycemia, glucose intolerance, and insulin resistance in liver and skeletal muscle of obese mice, and such effects were associated with activation of Akt and AMPK in these tissues. In conclusion, polyphenols from CBC show important therapeutic actions ameliorating obesity-associated complications. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Carlos M Donado-Pestana, Érika V M Pessoa, Larissa Rodrigues, Rafaela Rossi, Márcio H C Moura, Priscila R Dos Santos-Donado, Érique Castro, William T Festuccia, Maria Inés Genovese. Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice. Food chemistry. 2021 Mar 15;340:128169