Modeling drug transport within the viable skin - a review.

Joshua J Calcutt, Michael S Roberts, Yuri G Anissimov

Expert opinion on drug metabolism & toxicology 2021 Jan

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In the past, mathematical modeling of the transport of transdermal drugs has been primarily focused on the stratum corneum. However, the development of pharmaceutical technologies, such as chemical enhancers, iontophoresis, and microneedles, has led to two outcomes; an increase in permeability in the stratum corneum or the ability to negate the layer entirely. As a result, these outcomes have made the transport of a solute in the viable skin far more critical when studying transdermal drug delivery. The review will explicitly show the various attempts to model drug transport within the viable skin. Furthermore, a brief review will be conducted on the different models that explain stratum corneum transport, microneedle dynamics and estimation of the diffusion coefficient. Future development of mathematical models requires the focus to be changed from traditional diffusion-based tissue models to more sophisticated three-dimensional models that incorporate the physiology of the skin.

Citation

Joshua J Calcutt, Michael S Roberts, Yuri G Anissimov. Modeling drug transport within the viable skin - a review. Expert opinion on drug metabolism & toxicology. 2021 Jan;17(1):105-119