Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparum.

Timo Reiss, Hannah I Theis, Andres Gonzalez-Delgado, Joel Vega-Rodriguez, Peter F Zipfel, Christine Skerka, Gabriele Pradel

European journal of immunology 2021 Feb

filter terms:

We show that the intraerythrocytic stages of the malaria parasite Plasmodium falciparum bind plasminogen and mediate its conversion into plasmin to inactivate parasite-bound C3b. This complement evasion mechanism counteracts terminal complex formation and hence promotes parasite survival in human blood. © 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

Citation

Timo Reiss, Hannah I Theis, Andres Gonzalez-Delgado, Joel Vega-Rodriguez, Peter F Zipfel, Christine Skerka, Gabriele Pradel. Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparum. European journal of immunology. 2021 Feb;51(2):490-493