Severe metabolic acidosis due to acetazolamide intoxication in a dog.

L Johnston, E Leister, L Singer

Australian veterinary journal 2021 Jan

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This case report describes the clinical signs and case management of a 1-year-old neutered male Siberian Husky that accidentally ingested 635 mg/kg of oral acetazolamide (a carbonic anhydrase inhibitor). The dog presented with severe tachypnoea due to the development of hyperchloraemic metabolic acidosis and associated hypokalaemia that persisted for 7 days. Clinical and biochemical changes resolved with intravenous and subsequent oral supplementation of sodium bicarbonate and potassium. Complete recovery occurred within 9 days of presentation. To the authors' knowledge, this is the first case that reports overdosage of an oral carbonic anhydrase inhibitor in a dog and subsequent recovery with adequate supplementation and supportive care. © 2020 Australian Veterinary Association.

Citation

L Johnston, E Leister, L Singer. Severe metabolic acidosis due to acetazolamide intoxication in a dog. Australian veterinary journal. 2021 Jan;99(1-2):11-14