Host-guest interaction of cucurbit[8]uril with oroxin A and its effect on the properties of oroxin A.

In this study, we investigated the host-guest interactions between oroxin A (OA) and cucurbit[8]uril (Q[8]) using 1H NMR, MS, UV-vis and IR spectroscopy. The results showed that OA and Q[8] formed an inclusion compound (OA@Q[8]) with a molar ratio of 1:1 and a binding constant of 1.299 × 107 L·mol-1. In addition, the effect of Q[8] on the properties of OA was investigated through comparative experiments. The solubility of OA in water increased 22.47-fold when the concentration of Q[8] was 1 × 10-4 mol·L-1. Q[8] hardly affected the antioxidant capacity of OA, while the cumulative release of OA in gastric juice increased 2.3-fold after forming the inclusion compound with Q[8]. Copyright © 2020, Zeng et al.; licensee Beilstein-Institut.

Citation

Zhishu Zeng, Jun Xie, Guangyan Luo, Zhu Tao, Qianjun Zhang. Host-guest interaction of cucurbit[8]uril with oroxin A and its effect on the properties of oroxin A. Beilstein journal of organic chemistry. 2020;16:2332-2337

PMID: 33029251

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