Estriol in regulation of cell-mediated immune reactions in multiple sclerosis.

The effect of pregnancy hormone estriol (E3) on innate and adaptive immunity cells functions in patients with multiple sclerosis (MS) in comparison with healthy donors (HD) was studied. E3 inhibited phagocytic activity of neutrophils and enhanced monocytes IDO activity. Treg percentage increased and number of Th17 and iNKT cells decreased under E3 influence. At the same time, E3 stimulated production of IL-10 and inhibited secretion of IL-17. The hormonal effects were realized on the cells of both HD and MS patients. Thus, the MS amelioration during pregnancy may be related to E3 influence. Copyright © 2020 Elsevier B.V. All rights reserved.

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Irina Nekrasova, Sergei Shirshev. Estriol in regulation of cell-mediated immune reactions in multiple sclerosis. Journal of neuroimmunology. 2020 Dec 15;349:577421

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PMID: 33032016

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