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    Light-controlled sequential photolysis from a single nanoparticle is a challenge for controlled release. A wavelength-selective sequential photolysis from single gold nanoparticles is reported for the first time. In particular, it is also demonstrated that such nanoparticle can be used to sequentially release two payloads in living cells. In principle, this system can be extended to sequential release of multiple different types of payloads by rational design of diverse photocleavable linkers. It is expected that this work can provide a new tool for better orderly controlling cellular events that request high spatiotemporal manners. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


    Yekui Zhou, Yuanwei Zhang, Wenhai Lin, Samuel J Kesseli, Ling Huang, Yang Zhao, Xikuang Yao, Kai Huang, Gang Han. Wavelength-Selective Light-Controlled Stepwise Photolysis from Single Gold Nanoparticles. Advanced healthcare materials. 2021 Mar;10(5):e2000321

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    PMID: 33034955

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