Targeting DNA Repair Pathways in Hematological Malignancies.

Jehad F Alhmoud, Ayman G Mustafa, Mohammed Imad Malki

International journal of molecular sciences 2020 Oct 06

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DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple genomic changes that ultimately may result in mutation, tumor growth, and/or cell apoptosis. Furthermore, impaired repair mechanisms can also lead to genomic instability, which can initiate tumorigenesis and development of hematological malignancy. This review discusses recent findings and highlights the importance of DNA repair components and the impact of their aberrations on hematological malignancies.

Citation

Jehad F Alhmoud, Ayman G Mustafa, Mohammed Imad Malki. Targeting DNA Repair Pathways in Hematological Malignancies. International journal of molecular sciences. 2020 Oct 06;21(19)