A review on the structure and pharmacological activity of phenylethanoid glycosides.

Phenylethanoid glycosides (PhGs) are compounds made of phenylethyl alcohol, caffeic acid and glycosyl moieties. The first published references about phenylethanoid glycosides concerned the isolation of echinacoside from Echinaceu ungustifolia (Asteraceae) in 1950 and verbascoside from Verbascum sinuatum (Scrophulariaceae) in 1963. Over the past 60 years, many compounds with these structural characteristics have been isolated from natural sources, and most of these compounds possess significant bioactivities, including antibacterial, antitumor, antiviral, anti-inflammatory, neuro-protective, antioxidant, hepatoprotective, and immunomodulatory activities, among others. In this review, we will summarize the phenylethanoid glycosides described in recent papers and list all the compounds that have been isolated over the past few decades. We will also attempt to present and assess recent studies about the separation, extraction, determination, and pharmacological activity of the excellent natural components, phenylethanoid glycosides. Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Citation

Xiu-Yu Tian, Mao-Xing Li, Tong Lin, Yan Qiu, Yu-Ting Zhu, Xiao-Lin Li, Wen-Di Tao, Peng Wang, Xiao-Xia Ren, Li-Ping Chen. A review on the structure and pharmacological activity of phenylethanoid glycosides. European journal of medicinal chemistry. 2021 Jan 01;209:112563

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PMID: 33038797

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