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    Xylan extracted from corn cobs was used to produce mesalamine-loaded xylan microparticles (XMP5-ASA) by cross-linking polymerization using a non-hazardous cross-linking agent. The microparticles were characterized by thermal analysis (DSC/TG), X-ray diffraction (XRD), Infrared spectroscopy (FTIR-ATR) and scanning electron microscopy (SEM). A comparative study of the in vitro drug release from XMP5-ASA and from gastro-resistant capsules filled with XMP5-ASA (XMPCAP5-ASA) or 5-ASA was also performed. NMR, FTIR-ATR, XRD and DSC/TG studies indicated molecularly dispersed drug in the microparticles with increment on drug stability. The release studies showed that XMPCAP5-ASA allowed more efficient drug retention in the simulated gastric fluid and a prolonged drug release lasting up to 24 h. XMPCAP5-ASA retained approximately 48 % of its drug content after 6 h on the drug release assay. Thus, the encapsulation of 5-ASA into xylan microparticles together with gastro-resistant capsules allowed a better release control of the drug during different simulated gastrointestinal medium. Copyright © 2020 Elsevier Ltd. All rights reserved.


    Silvana Cartaxo da Costa Urtiga, Vitória Maria Oliveira Alves, Camila de Oliveira Melo, Marini Nascimento de Lima, Ernane Souza, Arcelina Pacheco Cunha, Nágila Maria Pontes Silva Ricardo, Elquio Eleamen Oliveira, Eryvaldo Sócrates Tabosa do Egito. Xylan microparticles for controlled release of mesalamine: Production and physicochemical characterization. Carbohydrate polymers. 2020 Dec 15;250:116929

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    PMID: 33049843

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