Effect of adjusting pH and chondroitin sulfate on the formation of curcumin-zein nanoparticles: Synthesis, characterization and morphology.

Simin Feng, Yuxin Sun, Dan Wang, Peilong Sun, Ping Shao

Carbohydrate polymers 2020 Dec 15

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This study is aiming to investigate the stabilizing effect of chondroitin sulfate (CS) on the preparation of curcumin nanoparticles (NPs). The results showed that adding CS before the anti-solvent process of zein (Z) at pH7 could fabricate most stable NPs (Cur/CS/Z-pH7) with particle size of 197 ± 5 nm and zeta-potential of -48.4 ± 1.9 mV. The pH had a significant effect on the fabrication of NPs. Cur/CS/Z-pH7 was more stable than Cur/CS/Z-pH3, while Cur/Z-CS-pH3 was more stable than the Cur/Z-CS-pH7. According to the results of XRD, FTIR, DSC and CD, CS can form irreversible macromolecular complexes with zein through non-electrostatic interactions during the anti-solvent process (Cur/CS/Z-pH7, Cur/CS/Z-pH3). However, CS was adsorbed on the surface of Zein NPs by electrostatic interaction (Cur/Z-CS-pH7, Cur/Z-CS-pH3), when CS was added after anti-solvent process of zein. These results illustrated that it is better to add CS before the anti-solvent process of zein at neutral pH. Copyright © 2020. Published by Elsevier Ltd.

Citation

Simin Feng, Yuxin Sun, Dan Wang, Peilong Sun, Ping Shao. Effect of adjusting pH and chondroitin sulfate on the formation of curcumin-zein nanoparticles: Synthesis, characterization and morphology. Carbohydrate polymers. 2020 Dec 15;250:116970