Is there a role of penicillin allergy in developing Clostridioides difficile infection?

Ralph Schwiebert, Jonathan Sandoe

Current opinion in gastroenterology 2021 Jan

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To explore the evidence for an association between penicillin allergy, antibiotic prescribing and Clostridioides difficile (CDI) infection. Several studies have highlighted the differences in antibiotic prescribing in penicillin allergic patients and the impact on rates of C. difficile infection. Penicillin allergy leads to higher incidences of prescriptions for antibiotics that are known to predispose to CDI. In turn CDI is more common in patients with penicillin allergy. Penicillin allergy is often erroneously ascribed to patients and should be challenged.

Citation

Ralph Schwiebert, Jonathan Sandoe. Is there a role of penicillin allergy in developing Clostridioides difficile infection? Current opinion in gastroenterology. 2021 Jan;37(1):1-3