Two Cases With Features of Lymphocyte Variant Hypereosinophilic Syndrome With STAT3 SH2 Domain Mutations.

Sebastian Fernandez-Pol, Bruce Petersen, Jo-Ellen Murphy, Jean S Oak, Erica B K Wang, Kerri E Rieger, Youn H Kim, Michael S Khodadoust, Carlos J Suarez

The American journal of surgical pathology 2021 Feb 01

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Lymphocyte variant hypereosinophilic syndrome (LV-HES) is a rare cause of eosinophilia that is due to eosinophilipoietic cytokine production by an immunophenotypically abnormal T-cell clone. The molecular pathogenesis of this disorder is largely unknown and only 1 case of LV-HES with a pathogenic STAT3 mutation has been described thus far. Here we report 2 cases of LV-HES with STAT3 SH2 domain mutations. These cases further support the model that activation of STAT3 signaling through STAT3 SH2 domain mutations is a recurrent event in LV-HES. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Sebastian Fernandez-Pol, Bruce Petersen, Jo-Ellen Murphy, Jean S Oak, Erica B K Wang, Kerri E Rieger, Youn H Kim, Michael S Khodadoust, Carlos J Suarez. Two Cases With Features of Lymphocyte Variant Hypereosinophilic Syndrome With STAT3 SH2 Domain Mutations. The American journal of surgical pathology. 2021 Feb 01;45(2):193-199