Cohort protocol: Guangzhou High-Risk Infant Cohort study.

Despite the increase in the survival rate of high-risk infants (HRIs) worldwide, the prevalence of motor and neurodevelopmental sequelae in such newborns has not shown concomitant improvement. Meanwhile, there are few cohorts that explore factors related to the development of HRIs in China. Therefore, the Guangzhou High-Risk Infant Cohort (GHRIC) has been designed to examine the complex relationships among a myriad of factors influencing growth and development in such children. The GHRIC study is a prospective cohort study that by the year 2023 will enrol an estimated total of 3000 HRIs from Guangzhou Women and Children's Medical Center (GWCMC) in Guangzhou, China. This study is designed to assess the growth and cognitive characteristics of HRIs and the risk factors affecting their development and prognoses. Data on risk factors, neurodevelopmental and cognitive-function evaluations, laboratory results, and specimens will be collected and analysed. Information on perinatal and clinical interventions for these infants will also be recorded during regular follow-up visits until age 6. The protocol for this study has been approved by the Research Ethics Committee of GWCMC, which accepted responsibility for supervising all of the aspects of the study (No. 2017102712). Study outcomes will be disseminated through conference presentations, peer-reviewed publications, the Internet and social media. ChiCTR-EOC-17013236. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Citation

Pian Hu, Azhu Han, Yan Hu, Yuqi Wen, Jingjing Liang, Wanqi Xiao, Suifang Lin, Yanyan Song, Xuying Tan, Xiaopeng Zhao, Haipeng Dong, Qianyun Liu, Huayan Zhang, Li Tao, Yuan Yuan. Cohort protocol: Guangzhou High-Risk Infant Cohort study. BMJ open. 2020 Oct 16;10(10):e037829

Mesh Tags

PMID: 33067281

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