Water Loss in Aging Erythrocytes Provides a Clue to a General Mechanism of Cellular Senescence.

Allen P Minton

Biophysical journal 2020 Nov 17

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Experimental evidence for age-dependent loss of intracellular water content as a widespread concomitant of cellular senescence is reviewed. Quantitative models are presented, indicating that an age-dependent increase in macromolecular crowding resulting from water loss may be responsible for three observed phenomena: a general age-dependent loss of intracellular protein solubility, a delayed and rapid appearance of high molecular weight aggregates, and an age-dependent transfer of intracellular protein from dilute to concentrated or condensed phases. Published by Elsevier Inc.

Citation

Allen P Minton. Water Loss in Aging Erythrocytes Provides a Clue to a General Mechanism of Cellular Senescence. Biophysical journal. 2020 Nov 17;119(10):2039-2044