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An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli.

Claudio Zambaldo, Minseob Koh, Fariborz Nasertorabi, Gye Won Han, Abhishek Chatterjee, Raymond C Stevens, Peter G Schultz

Bioorganic & medicinal chemistry 2020 Oct 15


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  • amino acids (4)
  • archaeoglobus fulgidus (2)
  • escherichia coli (3)
  • methanosarcina (1)
  • mutagenesis (1)
  • rna transfer (2)
  • rna transfer (2)
  • seryl trna (3)
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    We report the development of the orthogonal amber-suppressor pair Archaeoglobus fulgidus seryl-tRNA (Af-tRNASer)/Methanosarcina mazei seryl-tRNA synthetase (MmSerRS) in Escherichia coli. Furthermore, the crystal structure of MmSerRS was solved at 1.45 Å resolution, which should enable structure-guided engineering of its active site to genetically encode small, polar noncanonical amino acids (ncAAs). Copyright © 2020 Elsevier Ltd. All rights reserved.

    Citation

    Claudio Zambaldo, Minseob Koh, Fariborz Nasertorabi, Gye Won Han, Abhishek Chatterjee, Raymond C Stevens, Peter G Schultz. An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli. Bioorganic & medicinal chemistry. 2020 Oct 15;28(20):115662

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    PMID: 33069069

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