Phenolic glycosides from Oroxylum indicum.

Two new phenolic glycosides, oroxylumosides A (1) and B (2), along with four known compounds darendoside A (3), leucosceptoside A (4), acteoside (5) and decaffeoylacteoside (6) were isolated from the stem bark of Oroxylum indicum. Their structures were elucidated by extensive analysis of the 1 D and 2 D NMR as well as HR-ESI-QTOF-MS. In addition, compounds 1 - 4 exhibited inhibitory effects on NO production in LPS-stimulated BV2 microglial cell line with IC50 values of 58.2 ± 2.9, 70.6 ± 3.5, 56.8 ± 2.8 and 61.1 ± 3.1 µM, respectively.

Citation

Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen The Cuong, Nguyen Xuan Cuong, Hyuncheol Oh, Nguyen Van Sinh, Nguyen Hoai Nam, Chau Van Minh. Phenolic glycosides from Oroxylum indicum. Natural product research. 2022 May;36(9):2336-2340

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PMID: 33078632

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