Chemical constituents and absolute configuration of megastigmanes' isolated from Sedum sarmentosum Bunge.

Dinh Xuan Doan, Sijia Sun, Ashraf M Omar, Dong Thuong Nguyen, Anh Le Tuan Hoang, Hironori Fujiwara, Kinzo Matsumoto, Hang Thi Nguyet Pham, Suresh Awale

Natural product research 2022 May

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Phytochemical investigation of a methanolic extract of Sedum sarmentosum collected from Vietnam resulted in the isolation of a new megastigmane glucoside, named sedumoside K (1), together with 17 previously reported compounds (2-18). Structural elucidation of the new compound was achieved by HRFABMS, NMR spectroscopic analysis, acid hydrolysis and quantum ECD calculations. The absolute configuration of compounds 2-6 has been revised. The major isolates were tested for cytotoxic activity against HeLa human cervical cancer cells, and all showed moderate activities.

Citation

Dinh Xuan Doan, Sijia Sun, Ashraf M Omar, Dong Thuong Nguyen, Anh Le Tuan Hoang, Hironori Fujiwara, Kinzo Matsumoto, Hang Thi Nguyet Pham, Suresh Awale. Chemical constituents and absolute configuration of megastigmanes' isolated from Sedum sarmentosum Bunge. Natural product research. 2022 May;36(9):2341-2348