Effect of charge status on the ion transport and antimicrobial activity of synthetic channels.

Pengyang Xin, Lingyu Zhao, Linlin Mao, Linqi Xu, Shuaimin Hou, Huiyuan Kong, Haodong Fang, Haofeng Zhu, Tao Jiang, Chang-Po Chen

Chemical communications (Cambridge, England) 2020 Nov 18

filter terms:

A class of unimolecular channels formed by pillararene-gramicidin hybrid molecules are presented. The charge status of the peptide domain in these channels has a significant impact on their ion transport and antimicrobial activity. These channels exhibited different membrane-association abilities between microbial cells and mammalian cells. One of the channels displayed a higher antimicrobial activity towards S. aureus (IC50 = 0.55 μM) and negligible hemolytic toxicity, showing potential to serve as a systemic antibiotic.

Citation

Pengyang Xin, Lingyu Zhao, Linlin Mao, Linqi Xu, Shuaimin Hou, Huiyuan Kong, Haodong Fang, Haofeng Zhu, Tao Jiang, Chang-Po Chen. Effect of charge status on the ion transport and antimicrobial activity of synthetic channels. Chemical communications (Cambridge, England). 2020 Nov 18;56(89):13796-13799