Aurora kinases in ovarian cancer.

J Alejandro Pérez-Fidalgo, Valentina Gambardella, Begoña Pineda, Octavio Burgues, Oscar Piñero, Andrés Cervantes

ESMO open 2020 Oct

filter terms:

Aurora kinases (AURK) are key regulators of the mitotic spindle formation. AURK is frequently overexpressed in ovarian cancer and this overexpression has been frequently associated with prognosis in these tumours. Interestingly, AURK have been shown to interact with DNA repair mechanisms and other cell cycle regulators. These functions have brought light to Aurora family as a potential target for anticancer therapy. In the last years, two clinical trials with different AURK inhibitors have shown activity in epithelial and clear-cell ovarian cancer. Although there is a lack of predictive factors of AURK inhibition activity, recent trials have identified some candidates. This review will focus in the functions of the AURK family, its role as prognostic factor in epithelial ovarian cancer and potential clinical implications. © Author (s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology.

Citation

J Alejandro Pérez-Fidalgo, Valentina Gambardella, Begoña Pineda, Octavio Burgues, Oscar Piñero, Andrés Cervantes. Aurora kinases in ovarian cancer. ESMO open. 2020 Oct;5(5):e000718