Role of B Cells in Multiple Sclerosis and Related Disorders.

Annals of neurology 2021 Jan

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The success of clinical trials of selective B-cell depletion in patients with relapsing multiple sclerosis (MS) and primary progressive MS has led to a conceptual shift in the understanding of MS pathogenesis, away from the classical model in which T cells were the sole central actors and toward a more complex paradigm with B cells having an essential role in both the inflammatory and neurodegenerative components of the disease process. The role of B cells in MS was selected as the topic of the 27th Annual Meeting of the European Charcot Foundation. Results of the meeting are presented in this concise review, which recaps current concepts underlying the biology and therapeutic rationale behind B-cell-directed therapeutics in MS, and proposes strategies to optimize the use of existing anti-B-cell treatments and provide future directions for research in this area. ANN NEUROL 2021;89:13-23. © 2020 American Neurological Association.

Citation

Giancarlo Comi, Amit Bar-Or, Hans Lassmann, Antonio Uccelli, Hans-Peter Hartung, Xavier Montalban, Per Solberg Sørensen, Reinhard Hohlfeld, Stephen L Hauser, Expert Panel of the 27th Annual Meeting of the European Charcot Foundation. Role of B Cells in Multiple Sclerosis and Related Disorders. Annals of neurology. 2021 Jan;89(1):13-23