Correlation Engine 2.0
Clear Search sequence regions

  • dna repair (4)
  • humans (1)
  • hydrolysis (1)
  • recq helicases (8)
  • rna (1)
  • Sizes of these terms reflect their relevance to your search.

    Helicases are enzymes that use the energy derived from ATP hydrolysis to catalyze the unwinding of DNA or RNA. The RecQ family of helicases is conserved through evolution from prokaryotes to higher eukaryotes and plays important roles in various DNA repair pathways, contributing to the maintenance of genome integrity. Despite their roles as general tumor suppressors, there is now considerable interest in exploiting RecQ helicases as synthetic lethal targets for the development of new cancer therapeutics. In this review, we summarize the latest developments in the structural and mechanistic study of RecQ helicases and discuss their roles in various DNA repair pathways. Finally, we consider the potential to exploit RecQ helicases as therapeutic targets and review the recent progress towards the development of small molecules targeting RecQ helicases as cancer therapeutics. © 2020 The Author(s).


    Joseph A Newman, Opher Gileadi. RecQ helicases in DNA repair and cancer targets. Essays in biochemistry. 2020 Oct 26;64(5):819-830

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33095241

    View Full Text