Correlation Engine 2.0
Clear Search sequence regions

  • adult (1)
  • cancer (1)
  • female (1)
  • humans (1)
  • lentigo maligna (9)
  • margins (1)
  • men (1)
  • occult (1)
  • patient (3)
  • prognosis (1)
  • skin neoplasms (1)
  • tumor burden (1)
  • Sizes of these terms reflect their relevance to your search.

    There are no well-defined clinical factors to predict the risk of occult invasion in melanoma of the lentigo maligna type (LM) before complete histopathologic analysis. To evaluate whether clinical size was a predictor of invasion in LM and subclinical extension. Consecutive cases of LM were recorded in a prospectively maintained database from 2006 to 2019. Patient and tumor data were recorded during initial evaluation. The LM clinical area was calculated in square millimeters (length × width). All patients were treated with staged excision. We included 600 patients. The mean age was 65.9 years (standard deviation, 12.3; range, 27-95 years); 62.8% (n = 377) were men. The mean LM clinical area was 128.32 mm2 for in situ lesions versus 200.14 mm for invasive lesions (P = .1). Based on quantile regression, the median margin required for complete removal increased with LM clinical area. The study was performed in a tertiary cancer center with possible referral bias and more complex cases. LM can present with variable clinical size, which may correlate with subclinical extension; however, the presence of invasion is not well estimated by LM clinical area. Copyright © 2020 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.


    Cristian Navarrete-Dechent, Saud Aleissa, Karen Connolly, Brian P Hibler, Stephen W Dusza, Anthony M Rossi, Erica Lee, Kishwer S Nehal. Clinical size is a poor predictor of invasion in melanoma of the lentigo maligna type. Journal of the American Academy of Dermatology. 2021 May;84(5):1295-1301

    Expand section icon Mesh Tags

    PMID: 33096134

    View Full Text