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From the leaves of Ricinus communis Linn., one new alkaloid, named ricicomin A (1) together with three known ones, ricinine (2), N-demethylricinine (3) and 4-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid (4) were justified by repeated chromatographic methods. Their structures were determined by comprehensive IR, HR-ESI-MS and NMR analyses. Compound 4 was identified for the first time from the genus Ricinus. DFT-NMR chemical shift calculations and subsequent DP4+ probability methods were applied to confirm the chemical structure of 1. Compounds 1-3 did not display cytotoxic effect against three human cancer cell lines (MCF-7, HepG2 and HeLa) using SRB assay.


Nguyen Kim Tuyen Pham, Thi Thao Linh Tran, Thuc Huy Duong, Nguyen Tien Trung, Dang Cam Tu Phan, Dinh Tri Mai, Van Kieu Nguyen, Bui Linh Chi Huynh, Thi Anh Tuyet Nguyen, Trong Duc Tran, Thi Ngoc Mai Tran, Tan Phat Nguyen. Ricicomin A, a new alkaloid from the leaves of Ricinus communis Linn. Natural product research. 2022 Apr;36(8):1973-1979

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PMID: 33096957

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