The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress.

Elah Pick

Redox biology 2020 Oct

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Access of molecular oxygen to the respiratory electron transport chain at the mitochondria costs in the generation of reactive oxygen-derived species (ROS). ROS induces progressive damage to macromolecules in all living cells, hence, rapid defense mechanisms to maintain cellular redox home ostasis are vital. NEDD8/Rub1 is a highly conserved ubiquitin-like modifier that has recently been identified as a key regulator of cellular redox home ostasis. In this review, I will present NEDD8/Rub1, its modification cascade of enzymes, substrates and hydrolases. After introduction, I will show that the NEDD8/Rub1 pathway is linked with mitochondria physiology, namely, oxidative stress. In the rest of the review, I will approach the Ascomycota phylum of the kingdom fungi instrumentally, to present existing links between NEDD8/Rub1 vitality and the aerobic lifestyle of model species belonging to three subphyla: Saccharomycotina (S. cerevisiae and C. albicans), Pezizomycotina (A. nidulans and N. crassa), and Taphrinomycotina (S. pombe). Copyright © 2020 The Author. Published by Elsevier B.V. All rights reserved.

Citation

Elah Pick. The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress. Redox biology. 2020 Oct;37:101765